---
title: Medium StemFit used for cell cocultures (hiPS and hepatocytes)
description: StemFit and Bambanker were used for novel inter-organic interaction studies in drug tests
---

[NIPPON Genetics EUROPE News](https://news.nippongenetics.eu/en)

# [Medium StemFit used for cell cocultures (hiPS and hepatocytes)](https://news.nippongenetics.eu/en/stemfit-and-bambanker-used-for-novel-inter-organic-interaction-studies)

 Written by [Dr. Verena Krieger](https://news.nippongenetics.eu/en/author/dr.-verena-krieger) | May 6, 2021 8:13:30 AM

# Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system

Publication: Scientific Reports 11, 5437 (2021), M. Shinohara et al.

The study demonstrates the potential application of intestine–liver organ derived tissue perfusion cultures by using two-organ MPSs for the investigation of intestine–liver interactions in cell-based assays.

Examining intestine–liver interactions is important for achieving the desired physiological drug absorption and metabolism response in in vitro drug tests.

Multi-organ microphysiological systems (MPSs) constitute promising tools for evaluating inter-organ interactions in vitro.

Please find the full publication at: [https://doi.org/10.1038/s41598-021-84861-y](https://doi.org/10.1038/s41598-021-84861-y)

 

For coculture on MPSs, normal cells are challenging to use because they require complex maintenance and careful handling. hiPS-intestinal cells and PXB-cells were cocultured for 8 days in the pneumatic-pressure-driven two-organ MPSs:

 

In this study, the cultivation medium[StemFit](https://www.nippongenetics.eu/en/products/cell-biology/cell-culture-media-for-stem-cells-and-ips-cells/stemfit/) was used to maintain undifferentiated iPS cells on cell culture dishes. The collected endodermal cells were frozen in cryopreservation media [Bambanker hRM](https://www.nippongenetics.eu/en/products/cell-biology/freezing-media/for-ips-es-cells/bambanker-hrm/) for for storage.

   

[View full post](https://news.nippongenetics.eu/en/stemfit-and-bambanker-used-for-novel-inter-organic-interaction-studies)

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